产品货号：
GS4727
中文名称：
重组小鼠BRAK/CXCL14
英文名称：
Recombinant Murine Breast and Kindey-expressed Chemokine/CXCL14
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 9.4kDa,a single non-glycosylated polypeptide chain containing 77amino acids.
储存条件：冷冻（-20℃）
概述
Chemokine(C-X-C motif)ligand 14(CXCL14),also named BRAK,is a small cytokine belonging to the CXC chemokine family.It is constitutively expressed at the mRNA level in certain normal tissues and it possesses chemoattractive activity for activated macrophages,immature dendritic cells and natural killer cells.According to the relevant literature,CXCL14 is associated with tumor development.Moreover,recent evidence revealed that CXCL14 participates in glucose metabolism,feeding behaviour-associated neuronal circuits,and anti-microbial defense.Although CXCL14 receptors have not yet been identified,the intracellular activity of CXCL14 in breast cancer cells suggests that the CXCL14 receptor(s)and signal transduction pathway(s)may be different from those of conventional CXC-type chemokines.Recombinant murine CXCL14 contains 77 amino acid residues and it shares 97%and 99%a.a.sequence identity with human and rat CXCL14.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组小鼠BRAK/CXCL14，BRAK/CXCL14, Murine
储存条件：冷冻（-20℃）
概述
Chemokine(C-X-C motif)ligand 14(CXCL14),also named BRAK,is a small cytokine belonging to the CXC chemokine family.It is constitutively expressed at the mRNA level in certain normal tissues and it possesses chemoattractive activity for activated macrophages,immature dendritic cells and natural killer cells.According to the relevant literature,CXCL14 is associated with tumor development.Moreover,recent evidence revealed that CXCL14 participates in glucose metabolism,feeding behaviour-associated neuronal circuits,and anti-microbial defense.Although CXCL14 receptors have not yet been identified,the intracellular activity of CXCL14 in breast cancer cells suggests that the CXCL14 receptor(s)and signal transduction pathway(s)may be different from those of conventional CXC-type chemokines.Recombinant murine CXCL14 contains 77 amino acid residues and it shares 97%and 99%a.a.sequence identity with human and rat CXCL14.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 1.0-10ng/ml. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in 20mMPB,400 mM NaCl,pH 7.4,5%trehalose. |
| 内毒素 | Less than 1 EU/μg of rMuBRAK/CXCL14 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/ml.Stock solutions should be apportioned into working aliquots and stored at ≤-20?C.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIVTTKS MSRYRGQEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE |
相关搜索：重组小鼠BRAK/CXCL14，BRAK/CXCL14, Murine